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A lack of integration also plays a role, with poor screening for substance use disorders in both mental health and primary care settings, along with significant provider shortages in rural areas

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doi: 10.1016/j.ejphar.2018.01.037 54 MatthysPHatseSVermeireKWuytsABridgerGHensonGWet al

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Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz C, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrn E (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors